A Coumarin-Based Analogue of Thiacetazone as Dual Covalent Inhibitor and Potential Fluorescent Label of HadA in Mycobacterium tuberculosis

A novel coumarin-based molecule, designed as a fluorescent surrogate of a thiacetazone-derived antitubercular agent, was quickly and easily synthesized from readily available starting materials. This small molecule, coined as Coum-TAC, exhibited a combination of appropriate physicochemical and biolo...

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Publicado no:ACS Infect Dis
Main Authors: Farjallah, Asma, Chiarelli, Laurent R., Forbak, Martin, Degiacomi, Giulia, Danel, Mathieu, Goncalves, Fernanda, Carayon, Chantal, Seguin, Cendrine, Fumagalli, Marco, Záhorszká, Monika, Vega, Elodie, Abid, Souhir, Grzegorzewicz, Anna, Jackson, Mary, Peixoto, Antonio, Korduláková, Jana, Pasca, Maria Rosalia, Lherbet, Christian, Chassaing, Stefan
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8022203/
https://ncbi.nlm.nih.gov/pubmed/33617235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsinfecdis.0c00325
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