A Coumarin-Based Analogue of Thiacetazone as Dual Covalent Inhibitor and Potential Fluorescent Label of HadA in Mycobacterium tuberculosis

A novel coumarin-based molecule, designed as a fluorescent surrogate of a thiacetazone-derived antitubercular agent, was quickly and easily synthesized from readily available starting materials. This small molecule, coined as Coum-TAC, exhibited a combination of appropriate physicochemical and biolo...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:ACS Infect Dis
Egile Nagusiak: Farjallah, Asma, Chiarelli, Laurent R., Forbak, Martin, Degiacomi, Giulia, Danel, Mathieu, Goncalves, Fernanda, Carayon, Chantal, Seguin, Cendrine, Fumagalli, Marco, Záhorszká, Monika, Vega, Elodie, Abid, Souhir, Grzegorzewicz, Anna, Jackson, Mary, Peixoto, Antonio, Korduláková, Jana, Pasca, Maria Rosalia, Lherbet, Christian, Chassaing, Stefan
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2021
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC8022203/
https://ncbi.nlm.nih.gov/pubmed/33617235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsinfecdis.0c00325
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