Covalent Modification of the Mycobacterium tuberculosis FAS-II Dehydratase by Isoxyl and Thiacetazone

[Image: see text] Isoxyl (ISO) and thiacetazone (TAC) are two antitubercular prodrugs formerly used in the clinical treatment of tuberculosis. Although both prodrugs have recently been shown to kill Mycobacterium tuberculosis through the inhibition of the dehydration step of the type II fatty acid s...

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Bibliografski detalji
Izdano u:ACS Infect Dis
Glavni autori: Grzegorzewicz, Anna E., Eynard, Nathalie, Quémard, Annaïk, North, E. Jeffrey, Margolis, Alyssa, Lindenberger, Jared J., Jones, Victoria, Korduláková, Jana, Brennan, Patrick J., Lee, Richard E., Ronning, Donald R., McNeil, Michael R., Jackson, Mary
Format: Artigo
Jezik:Inglês
Izdano: American Chemical Society 2014
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4401429/
https://ncbi.nlm.nih.gov/pubmed/25897434
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/id500032q
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