Discovery of a novel dehydratase of the fatty acid synthase type II critical for ketomycolic acid biosynthesis and virulence of Mycobacterium tuberculosis

The fatty acid synthase type II (FAS-II) multienzyme system builds the main chain of mycolic acids (MAs), important lipid pathogenicity factors of Mycobacterium tuberculosis (Mtb). Due to their original structure, the identification of the (3 R)-hydroxyacyl-ACP dehydratases, HadAB and HadBC, of Mtb...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Lefebvre, Cyril, Frigui, Wafa, Slama, Nawel, Lauzeral-Vizcaino, Françoise, Constant, Patricia, Lemassu, Anne, Parish, Tanya, Eynard, Nathalie, Daffé, Mamadou, Brosch, Roland, Quémard, Annaïk
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7005898/
https://ncbi.nlm.nih.gov/pubmed/32034201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-58967-8
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