HadD, a novel fatty acid synthase type II protein, is essential for alpha- and epoxy-mycolic acid biosynthesis and mycobacterial fitness

Mycolic acids (MAs) have a strategic location within the mycobacterial envelope, deeply influencing its architecture and permeability, and play a determinant role in the pathogenicity of mycobacteria. The fatty acid synthase type II (FAS-II) multienzyme system is involved in their biosynthesis. A co...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Lefebvre, Cyril, Boulon, Richard, Ducoux, Manuelle, Gavalda, Sabine, Laval, Françoise, Jamet, Stevie, Eynard, Nathalie, Lemassu, Anne, Cam, Kaymeuang, Bousquet, Marie-Pierre, Bardou, Fabienne, Burlet-Schiltz, Odile, Daffé, Mamadou, Quémard, Annaïk
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5902629/
https://ncbi.nlm.nih.gov/pubmed/29662082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-24380-5
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