The Pks13/FadD32 Crosstalk for the Biosynthesis of Mycolic Acids in Mycobacterium tuberculosis

The last steps of the biosynthesis of mycolic acids, essential and specific lipids of Mycobacterium tuberculosis and related bacteria, are catalyzed by proteins encoded by the fadD32-pks13-accD4 cluster. Here, we produced and purified an active form of the Pks13 polyketide synthase, with a phosphopa...

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Hauptverfasser: Gavalda, Sabine, Léger, Mathieu, van der Rest, Benoît, Stella, Alexandre, Bardou, Fabienne, Montrozier, Henri, Chalut, Christian, Burlet-Schiltz, Odile, Marrakchi, Hedia, Daffé, Mamadou, Quémard, Annaïk
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2009
Schlagworte:
Enzyme Catalysis and Regulation
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2740550/
https://ncbi.nlm.nih.gov/pubmed/19436070
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.006940
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