Adenosine Modification May Be Preferred for Reducing siRNA Immune Stimulation

by Fucini, Raymond V., Haringsma, Henry J., Deng, Patricia, Flanagan, W. Michael, Willingham, Aarron T.
Published 2012

mRNA knockdown by single strand RNA is improved by chemical modifications

by Haringsma, Henry J., Li, Jenny J., Soriano, Ferdie, Kenski, Denise M., Flanagan, W. Michael, Willingham, Aarron T.
Published 2012

Nucleobase and Ribose Modifications Control Immunostimulation by a MicroRNA-122-mimetic RNA

by Peacock, Hayden, Fucini, Raymond V., Jayalath, Prasanna, Ibarra-Soza, José M., Haringsma, Henry J., Flanagan, W. Michael, Willingham, Aarron, Beal, Peter A.
Published 2011

Analysis of acyclic nucleoside modifications in siRNAs finds sensitivity at position 1 that is restored by 5′-terminal phosphorylation both in vitro and in vivo

by Kenski, Denise M., Cooper, Abby J., Li, Jenny J., Willingham, Aarron T., Haringsma, Henry J., Young, Tracy A., Kuklin, Nelly A., Jones, Jeffrey J., Cancilla, Mark T., McMasters, Daniel R., Mathur, Melina, Sachs, Alan B., Flanagan, W. Michael
Published 2010

Inactivation of Capicua drives cancer metastasis

by Okimoto, Ross A., Breitenbuecher, Frank, Olivas, Victor R., Wu, Wei, Gini, Beatrice, Hofree, Matan, Asthana, Saurabh, Hrustanovic, Gorjan, Flanagan, Jennifer, Tulpule, Asmin, Blakely, Collin M., Haringsma, Henry J., Simmons, Andrew D., Gowen, Kyle, Suh, James, Miller, Vincent A., Ali, Siraj, Schuler, Martin, Bivona, Trever G.
Published in Nat Genet (2016)

Hsp90 Inhibition Suppresses Mutant EGFR-T790M Signaling and Overcomes Kinase Inhibitor Resistance

by Shimamura, Takeshi, Li, Danan, Ji, Hongbin, Haringsma, Henry J., Liniker, Elizabeth, Borgman, Christa L., Lowell, April M., Minami, Yuko, McNamara, Kate, Perera, Samanthi A., Zaghlul, Sara, Thomas, Roman K., Greulich, Heidi, Kobayashi, Susumu, Chirieac, Lucian R., Padera, Robert F., Kubo, Shigeto, Takahashi, Masaya, Tenen, Daniel G., Meyerson, Matthew, Wong, Kwok-Kin, Shapiro, Geoffrey I.
Published 2008

Circulating tumour DNA profiling reveals heterogeneity of EGFR inhibitor resistance mechanisms in lung cancer patients

by Chabon, Jacob J., Simmons, Andrew D., Lovejoy, Alexander F., Esfahani, Mohammad S., Newman, Aaron M., Haringsma, Henry J., Kurtz, David M., Stehr, Henning, Scherer, Florian, Karlovich, Chris A., Harding, Thomas C., Durkin, Kathleen A., Otterson, Gregory A., Purcell, W. Thomas, Camidge, D. Ross, Goldman, Jonathan W., Sequist, Lecia V., Piotrowska, Zofia, Wakelee, Heather A., Neal, Joel W., Alizadeh, Ash A., Diehn, Maximilian
Published in Nat Commun (2016)

Corrigendum: Circulating tumour DNA profiling reveals heterogeneity of EGFR inhibitor resistance mechanisms in lung cancer patients

by Chabon, Jacob J., Simmons, Andrew D., Lovejoy, Alexander F., Esfahani, Mohammad S., Newman, Aaron M., Haringsma, Henry J., Kurtz, David M., Stehr, Henning, Scherer, Florian, Karlovich, Chris A., Harding, Thomas C., Durkin, Kathleen A., Otterson, Gregory A., Thomas Purcell, W., Ross Camidge, D., Goldman, Jonathan W., Sequist, Lecia V., Piotrowska, Zofia, Wakelee, Heather A., Neal, Joel W., Alizadeh, Ash A., Diehn, Maximilian
Published in Nat Commun (2016)

Aurora kinase A drives the evolution of resistance to third generation EGFR inhibitors in lung cancer

by Shah, Khyati N., Bhatt, Roma, Rotow, Julia, Rohrberg, Julia, Olivas, Victor, Wang, Victoria E., Hemmati, Golzar, Martins, Maria M., Maynard, Ashley, Kuhn, Jonathan, Galeas, Jacqueline, Donnella, Hayley J., Kaushik, Swati, Ku, Angel, Dumont, Sophie, Krings, Gregor, Haringsma, Henry J., Robillard, Liliane, Simmons, Andrew D., Harding, Thomas C., McCormick, Frank, Goga, Andrei, Blakely, Collin M., Bivona, Trever G., Bandyopadhyay, Sourav
Published in Nat Med (2018)

Discovery of a mutant-selective covalent inhibitor of EGFR that overcomes T790M-mediated resistance in NSCLC

by Walter, Annette O., Sjin, Robert Tjin Tham, Haringsma, Henry J., Ohashi, Kadoaki, Sun, Jing, Lee, Kwangho, Dubrovskiy, Aleksander, Labenski, Matthew, Zhu, Zhendong, Wang, Zhigang, Sheets, Michael, Martin, Thia St, Karp, Russell, van Kalken, Dan, Chaturvedi, Prasoon, Niu, Deqiang, Nacht, Mariana, Petter, Russell C., Westlin, William, Lin, Kevin, Jaw-Tsai, Sarah, Raponi, Mitch, Dyke, Terry Van, Etter, Jeff, Weaver, Zoe, Pao, William, Singh, Juswinder, Simmons, Andrew D., Harding, Thomas C., Allen, Andrew
Published 2013