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Aurora kinase A drives the evolution of resistance to third generation EGFR inhibitors in lung cancer
Although targeted therapies often elicit profound initial patient responses, these effects are transient due to residual disease leading to acquired resistance. How tumors transition between drug responsiveness, tolerance and resistance, especially in the absence of pre-existing subclones, remains u...
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| Publicado no: | Nat Med |
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| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6324945/ https://ncbi.nlm.nih.gov/pubmed/30478424 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41591-018-0264-7 |
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