Differential subcellular localization regulates oncogenic signaling by ROS1 kinase fusion proteins

Chromosomal rearrangements involving receptor tyrosine kinases (RTK) are a clinically relevant oncogenic mechanism in human cancers. These chimeric oncoproteins often contain the C-terminal kinase domain of the RTK joined in cis to various N-terminal, non-kinase fusion partners. The functional role...

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Detalhes bibliográficos
Publicado no:Cancer Res
Main Authors: Neel, Dana S., Allegakoen, David V., Olivas, Victor, Mayekar, Manasi K., Hemmati, Golzar, Chatterjee, Nilanjana, Blakely, Collin M., McCoach, Caroline E., Rotow, Julia K., Le, Anh, Karachaliou, Niki, Rosell, Rafael, Riess, Jonathan W., Nichols, Robert, Doebele, Robert C., Bivona, Trever G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6359944/
https://ncbi.nlm.nih.gov/pubmed/30538120
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-18-1492
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