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Adenosine Modification May Be Preferred for Reducing siRNA Immune Stimulation
The immune stimulation induced by short interfering RNAs (siRNAs) has been reported to be quieted or abrogated by methoxy or fluoro modifications of the 2′ position of the ribose sugar. However, variables such as the type of modification, nucleotide preference, and strand bias have not been systemat...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Mary Ann Liebert, Inc.
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4047996/ https://ncbi.nlm.nih.gov/pubmed/22519815 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/nat.2011.0334 |
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