mRNA knockdown by single strand RNA is improved by chemical modifications

While RNAi has traditionally relied on RNA duplexes, early evaluation of siRNAs demonstrated activity of the guide strand in the absence of the passenger strand. However, these single strands lacked the activity of duplex RNAs. Here, we report the systematic use of chemical modifications to optimize...

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Detalles Bibliográficos
Main Authors: Haringsma, Henry J., Li, Jenny J., Soriano, Ferdie, Kenski, Denise M., Flanagan, W. Michael, Willingham, Aarron T.
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2012
Assuntos:
RNA
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3351186/
https://ncbi.nlm.nih.gov/pubmed/22253019
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr1301
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