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mRNA knockdown by single strand RNA is improved by chemical modifications
While RNAi has traditionally relied on RNA duplexes, early evaluation of siRNAs demonstrated activity of the guide strand in the absence of the passenger strand. However, these single strands lacked the activity of duplex RNAs. Here, we report the systematic use of chemical modifications to optimize...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Oxford University Press
2012
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3351186/ https://ncbi.nlm.nih.gov/pubmed/22253019 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr1301 |
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