mRNA knockdown by single strand RNA is improved by chemical modifications

While RNAi has traditionally relied on RNA duplexes, early evaluation of siRNAs demonstrated activity of the guide strand in the absence of the passenger strand. However, these single strands lacked the activity of duplex RNAs. Here, we report the systematic use of chemical modifications to optimize...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Haringsma, Henry J., Li, Jenny J., Soriano, Ferdie, Kenski, Denise M., Flanagan, W. Michael, Willingham, Aarron T.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Oxford University Press 2012
Gaiak:
RNA
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3351186/
https://ncbi.nlm.nih.gov/pubmed/22253019
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr1301
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