Single-stranded microRNA mimics

miRNAs are ∼22-nt RNAs that bind to the Argonaute family of proteins and have important regulatory roles in plants and animals. Here, we show that miRNAs exhibit targeting activity in cells when delivered as single strands that are 5′-phosphorylated and that contain 2′-fluoro ribose modifications. L...

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Bibliografiske detaljer
Main Authors: Chorn, Guillaume, Klein-McDowell, Molly, Zhao, Lihong, Saunders, Matthew A., Flanagan, W. Michael, Willingham, Aarron T., Lim, Lee P.
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 2012
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3446704/
https://ncbi.nlm.nih.gov/pubmed/22912485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.031278.111
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