Nucleobase and Ribose Modifications Control Immunostimulation by a MicroRNA-122-mimetic RNA

Immune stimulation is a significant hurdle in the development of effective and safe RNA interference therapeutics. Here, we address this problem in the context of a mimic of microRNA-122 by employing novel nucleobase and known 2′-ribose modifications. The nucleobase modifications are analogues of ad...

Volledige beschrijving

Bewaard in:
Bibliografische gegevens
Hoofdauteurs: Peacock, Hayden, Fucini, Raymond V., Jayalath, Prasanna, Ibarra-Soza, José M., Haringsma, Henry J., Flanagan, W. Michael, Willingham, Aarron, Beal, Peter A.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2011
Onderwerpen:
Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3116021/
https://ncbi.nlm.nih.gov/pubmed/21612237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja202492e
Tags: Voeg label toe
Geen labels, Wees de eerste die dit record labelt!

Gelijkaardige items