Nucleobase modification by an RNA enzyme

Ribozymes can catalyze phosphoryl or nucleotidyl transfer onto ribose hydroxyls of RNA chains. We report a single ribozyme that performs both reactions, with a nucleobase serving as initial acceptor moiety. This unprecedented combined reaction was revealed while investigating potential contributions...

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Pubblicato in:Nucleic Acids Res
Autori principali: Poudyal, Raghav R., Nguyen, Phuong D. M., Lokugamage, Melissa P., Callaway, Mackenzie K., Gavette, Jesse V., Krishnamurthy, Ramanarayanan, Burke, Donald H.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2017
Soggetti:
Nucleic Acid Enzymes
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5388400/
https://ncbi.nlm.nih.gov/pubmed/28180302
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw1199
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