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The human tRNA taurine modification enzyme GTPBP3 is an active GTPase linked to mitochondrial diseases

GTPBP3 and MTO1 cooperatively catalyze 5-taurinomethyluridine (τm(5)U) biosynthesis at the 34(th) wobble position of mitochondrial tRNAs. Mutations in tRNAs, GTPBP3 or MTO1, causing τm(5)U hypomodification, lead to various diseases. However, efficient in vitro reconstitution and mechanistic study of...

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Bibliografski detalji
Izdano u:Nucleic Acids Res
Glavni autori: Peng, Gui-Xin, Zhang, Yong, Wang, Qin-Qin, Li, Qing-Run, Xu, Hong, Wang, En-Duo, Zhou, Xiao-Long
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2021
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7969015/
https://ncbi.nlm.nih.gov/pubmed/33619562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkab104
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