The human tRNA taurine modification enzyme GTPBP3 is an active GTPase linked to mitochondrial diseases

GTPBP3 and MTO1 cooperatively catalyze 5-taurinomethyluridine (τm(5)U) biosynthesis at the 34(th) wobble position of mitochondrial tRNAs. Mutations in tRNAs, GTPBP3 or MTO1, causing τm(5)U hypomodification, lead to various diseases. However, efficient in vitro reconstitution and mechanistic study of...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Nucleic Acids Res
Prif Awduron: Peng, Gui-Xin, Zhang, Yong, Wang, Qin-Qin, Li, Qing-Run, Xu, Hong, Wang, En-Duo, Zhou, Xiao-Long
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Oxford University Press 2021
Pynciau:
Nucleic Acid Enzymes
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7969015/
https://ncbi.nlm.nih.gov/pubmed/33619562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkab104
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