The human tRNA taurine modification enzyme GTPBP3 is an active GTPase linked to mitochondrial diseases

GTPBP3 and MTO1 cooperatively catalyze 5-taurinomethyluridine (τm(5)U) biosynthesis at the 34(th) wobble position of mitochondrial tRNAs. Mutations in tRNAs, GTPBP3 or MTO1, causing τm(5)U hypomodification, lead to various diseases. However, efficient in vitro reconstitution and mechanistic study of...

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Bibliografiske detaljer
Udgivet i:Nucleic Acids Res
Main Authors: Peng, Gui-Xin, Zhang, Yong, Wang, Qin-Qin, Li, Qing-Run, Xu, Hong, Wang, En-Duo, Zhou, Xiao-Long
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2021
Fag:
Nucleic Acid Enzymes
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7969015/
https://ncbi.nlm.nih.gov/pubmed/33619562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkab104
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