The human tRNA taurine modification enzyme GTPBP3 is an active GTPase linked to mitochondrial diseases

GTPBP3 and MTO1 cooperatively catalyze 5-taurinomethyluridine (τm(5)U) biosynthesis at the 34(th) wobble position of mitochondrial tRNAs. Mutations in tRNAs, GTPBP3 or MTO1, causing τm(5)U hypomodification, lead to various diseases. However, efficient in vitro reconstitution and mechanistic study of...

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Detaylı Bibliyografya
Yayımlandı:Nucleic Acids Res
Asıl Yazarlar: Peng, Gui-Xin, Zhang, Yong, Wang, Qin-Qin, Li, Qing-Run, Xu, Hong, Wang, En-Duo, Zhou, Xiao-Long
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Oxford University Press 2021
Konular:
Nucleic Acid Enzymes
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7969015/
https://ncbi.nlm.nih.gov/pubmed/33619562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkab104
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