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The human tRNA taurine modification enzyme GTPBP3 is an active GTPase linked to mitochondrial diseases
GTPBP3 and MTO1 cooperatively catalyze 5-taurinomethyluridine (τm(5)U) biosynthesis at the 34(th) wobble position of mitochondrial tRNAs. Mutations in tRNAs, GTPBP3 or MTO1, causing τm(5)U hypomodification, lead to various diseases. However, efficient in vitro reconstitution and mechanistic study of...
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| Veröffentlicht in: | Nucleic Acids Res |
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| Hauptverfasser: | , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Oxford University Press
2021
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7969015/ https://ncbi.nlm.nih.gov/pubmed/33619562 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkab104 |
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