The human tRNA taurine modification enzyme GTPBP3 is an active GTPase linked to mitochondrial diseases

GTPBP3 and MTO1 cooperatively catalyze 5-taurinomethyluridine (τm(5)U) biosynthesis at the 34(th) wobble position of mitochondrial tRNAs. Mutations in tRNAs, GTPBP3 or MTO1, causing τm(5)U hypomodification, lead to various diseases. However, efficient in vitro reconstitution and mechanistic study of...

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Bibliografiset tiedot
Julkaisussa:Nucleic Acids Res
Päätekijät: Peng, Gui-Xin, Zhang, Yong, Wang, Qin-Qin, Li, Qing-Run, Xu, Hong, Wang, En-Duo, Zhou, Xiao-Long
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Oxford University Press 2021
Aiheet:
Nucleic Acid Enzymes
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7969015/
https://ncbi.nlm.nih.gov/pubmed/33619562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkab104
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