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A nucleobase-binding pocket in a viral RNA-dependent RNA polymerase contributes to elongation complex stability
The enterovirus 71 (EV71) 3D(pol) is an RNA-dependent RNA polymerase (RdRP) that plays the central role in the viral genome replication, and is an important target in antiviral studies. Here, we report a crystal structure of EV71 3D(pol) elongation complex (EC) at 1.8 Å resolution. The structure rev...
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| Publicado no: | Nucleic Acids Res |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7026628/ https://ncbi.nlm.nih.gov/pubmed/31863580 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz1170 |
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