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Active site closure stabilizes the backtracked state of RNA polymerase
All cellular RNA polymerases (RNAP) occasionally backtrack along the template DNA as part of transcriptional proofreading and regulation. Here, we studied the mechanism of RNAP backtracking by one nucleotide using two complementary approaches that allowed us to precisely measure the occupancy and li...
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| Publicado no: | Nucleic Acids Res |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6237748/ https://ncbi.nlm.nih.gov/pubmed/30256972 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky883 |
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