Active site opening and closure control translocation of multisubunit RNA polymerase

Multisubunit RNA polymerase (RNAP) is the central information-processing enzyme in all cellular life forms, yet its mechanism of translocation along the DNA molecule remains conjectural. Here, we report direct monitoring of bacterial RNAP translocation following the addition of a single nucleotide....

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Bibliographic Details
Main Authors: Malinen, Anssi M., Turtola, Matti, Parthiban, Marimuthu, Vainonen, Lioudmila, Johnson, Mark S., Belogurov, Georgiy A.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2012
Subjects:
Nucleic Acid Enzymes
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3424550/
https://ncbi.nlm.nih.gov/pubmed/22570421
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks383
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