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CBR antimicrobials alter coupling between the bridge helix and the β subunit in RNA polymerase
Bacterial RNA polymerase (RNAP) is a validated target for antibacterial drugs. CBR703 series antimicrobials allosterically inhibit transcription by binding to a conserved α helix (β′ bridge helix, BH) that interconnects the two largest RNAP subunits. Here we show that disruption of the BH-β subunit...
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| Главные авторы: | , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Nature Pub. Group
2014
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3959191/ https://ncbi.nlm.nih.gov/pubmed/24598909 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms4408 |
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