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Active site closure stabilizes the backtracked state of RNA polymerase

All cellular RNA polymerases (RNAP) occasionally backtrack along the template DNA as part of transcriptional proofreading and regulation. Here, we studied the mechanism of RNAP backtracking by one nucleotide using two complementary approaches that allowed us to precisely measure the occupancy and li...

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Dades bibliogràfiques
Publicat a:Nucleic Acids Res
Autors principals: Turtola, Matti, Mäkinen, Janne J, Belogurov, Georgiy A
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2018
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6237748/
https://ncbi.nlm.nih.gov/pubmed/30256972
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky883
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