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Nucleobase and Ribose Modifications Control Immunostimulation by a MicroRNA-122-mimetic RNA

Immune stimulation is a significant hurdle in the development of effective and safe RNA interference therapeutics. Here, we address this problem in the context of a mimic of microRNA-122 by employing novel nucleobase and known 2′-ribose modifications. The nucleobase modifications are analogues of ad...

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Detalhes bibliográficos
Main Authors: Peacock, Hayden, Fucini, Raymond V., Jayalath, Prasanna, Ibarra-Soza, José M., Haringsma, Henry J., Flanagan, W. Michael, Willingham, Aarron, Beal, Peter A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3116021/
https://ncbi.nlm.nih.gov/pubmed/21612237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja202492e
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