Inactivation of Capicua drives cancer metastasis

Metastasis is the leading cause of death in lung cancer patients, yet the molecular effectors underlying tumor dissemination remain poorly defined. Through development of an in vivo spontaneous lung cancer metastasis model, we show that the developmentally-regulated transcriptional repressor Capicua...

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Publicat a:Nat Genet
Autors principals: Okimoto, Ross A., Breitenbuecher, Frank, Olivas, Victor R., Wu, Wei, Gini, Beatrice, Hofree, Matan, Asthana, Saurabh, Hrustanovic, Gorjan, Flanagan, Jennifer, Tulpule, Asmin, Blakely, Collin M., Haringsma, Henry J., Simmons, Andrew D., Gowen, Kyle, Suh, James, Miller, Vincent A., Ali, Siraj, Schuler, Martin, Bivona, Trever G.
Format: Artigo
Idioma:Inglês
Publicat: 2016
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5195898/
https://ncbi.nlm.nih.gov/pubmed/27869830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.3728
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