RAS-MAPK dependence underlies a rational polytherapy strategy in EML4-ALK–positive lung cancer

One strategy for combating cancer-drug resistance is to deploy rational polytherapy up front that suppresses the survival and emergence of resistant tumor cells. Here we demonstrate in models of lung adenocarcinoma harboring the oncogenic fusion of ALK and EML4 that the GTPase RAS–mitogen-activated...

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Pubblicato in:Nat Med
Autori principali: Hrustanovic, Gorjan, Olivas, Victor, Pazarentzos, Evangelos, Tulpule, Asmin, Asthana, Saurabh, Blakely, Collin M, Okimoto, Ross A, Lin, Luping, Neel, Dana S, Sabnis, Amit, Flanagan, Jennifer, Chan, Elton, Varella-Garcia, Marileila, Aisner, Dara L, Vaishnavi, Aria, Ou, Sai-Hong I, Collisson, Eric A, Ichihara, Eiki, Mack, Philip C, Lovly, Christine M, Karachaliou, Niki, Rosell, Rafael, Riess, Jonathan W, Doebele, Robert C, Bivona, Trever G
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4734742/
https://ncbi.nlm.nih.gov/pubmed/26301689
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.3930
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