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RAS signaling in ALK fusion lung cancer
The success of ALK targeted therapy is blunted by resistance. To identify rational polytherapy strategies to improve clinical outcomes, we studied the molecular basis of ALK oncogene dependence in ALK gene rearrangement positive (ALK+) lung adenocarcinoma. We discovered that RAS-RAF-MEK-ERK signalin...
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| Publicado no: | Small GTPases |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Taylor & Francis
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4905280/ https://ncbi.nlm.nih.gov/pubmed/26901483 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/21541248.2015.1131803 |
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