Circulating tumour DNA profiling reveals heterogeneity of EGFR inhibitor resistance mechanisms in lung cancer patients

Circulating tumour DNA (ctDNA) analysis facilitates studies of tumour heterogeneity. Here we employ CAPP-Seq ctDNA analysis to study resistance mechanisms in 43 non-small cell lung cancer (NSCLC) patients treated with the third-generation epidermal growth factor receptor (EGFR) inhibitor rociletinib...

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Bibliografske podrobnosti
izdano v:Nat Commun
Main Authors: Chabon, Jacob J., Simmons, Andrew D., Lovejoy, Alexander F., Esfahani, Mohammad S., Newman, Aaron M., Haringsma, Henry J., Kurtz, David M., Stehr, Henning, Scherer, Florian, Karlovich, Chris A., Harding, Thomas C., Durkin, Kathleen A., Otterson, Gregory A., Purcell, W. Thomas, Camidge, D. Ross, Goldman, Jonathan W., Sequist, Lecia V., Piotrowska, Zofia, Wakelee, Heather A., Neal, Joel W., Alizadeh, Ash A., Diehn, Maximilian
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2016
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4906406/
https://ncbi.nlm.nih.gov/pubmed/27283993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms11815
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