Integrated digital error suppression for improved detection of circulating tumor DNA

High-throughput sequencing of circulating tumor DNA (ctDNA) promises to facilitate personalized cancer therapy. However, low quantities of cell-free DNA (cfDNA) in the blood and sequencing artifacts currently limit analytical sensitivity. To overcome these limitations, we introduce an approach for i...

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Detalhes bibliográficos
Publicado no:Nat Biotechnol
Main Authors: Newman, Aaron M., Lovejoy, Alexander F., Klass, Daniel M., Kurtz, David M., Chabon, Jacob J., Scherer, Florian, Stehr, Henning, Liu, Chih Long, Bratman, Scott V., Say, Carmen, Zhou, Li, Carter, Justin N., West, Robert B., Sledge, George W., Shrager, Joseph B., Loo, Billy W., Neal, Joel W., Wakelee, Heather A., Diehn, Maximilian, Alizadeh, Ash A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4907374/
https://ncbi.nlm.nih.gov/pubmed/27018799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt.3520
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