Integrated digital error suppression for improved detection of circulating tumor DNA

High-throughput sequencing of circulating tumor DNA (ctDNA) promises to facilitate personalized cancer therapy. However, low quantities of cell-free DNA (cfDNA) in the blood and sequencing artifacts currently limit analytical sensitivity. To overcome these limitations, we introduce an approach for i...

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Bibliografske podrobnosti
izdano v:Nat Biotechnol
Main Authors: Newman, Aaron M., Lovejoy, Alexander F., Klass, Daniel M., Kurtz, David M., Chabon, Jacob J., Scherer, Florian, Stehr, Henning, Liu, Chih Long, Bratman, Scott V., Say, Carmen, Zhou, Li, Carter, Justin N., West, Robert B., Sledge, George W., Shrager, Joseph B., Loo, Billy W., Neal, Joel W., Wakelee, Heather A., Diehn, Maximilian, Alizadeh, Ash A.
Format: Artigo
Jezik:Inglês
Izdano: 2016
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4907374/
https://ncbi.nlm.nih.gov/pubmed/27018799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt.3520
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