Integrated digital error suppression for improved detection of circulating tumor DNA

High-throughput sequencing of circulating tumor DNA (ctDNA) promises to facilitate personalized cancer therapy. However, low quantities of cell-free DNA (cfDNA) in the blood and sequencing artifacts currently limit analytical sensitivity. To overcome these limitations, we introduce an approach for i...

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Publicado en:Nat Biotechnol
Autores principales: Newman, Aaron M., Lovejoy, Alexander F., Klass, Daniel M., Kurtz, David M., Chabon, Jacob J., Scherer, Florian, Stehr, Henning, Liu, Chih Long, Bratman, Scott V., Say, Carmen, Zhou, Li, Carter, Justin N., West, Robert B., Sledge, George W., Shrager, Joseph B., Loo, Billy W., Neal, Joel W., Wakelee, Heather A., Diehn, Maximilian, Alizadeh, Ash A.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2016
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4907374/
https://ncbi.nlm.nih.gov/pubmed/27018799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt.3520
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