Integrated digital error suppression for improved detection of circulating tumor DNA

High-throughput sequencing of circulating tumor DNA (ctDNA) promises to facilitate personalized cancer therapy. However, low quantities of cell-free DNA (cfDNA) in the blood and sequencing artifacts currently limit analytical sensitivity. To overcome these limitations, we introduce an approach for i...

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Pubblicato in:Nat Biotechnol
Autori principali: Newman, Aaron M., Lovejoy, Alexander F., Klass, Daniel M., Kurtz, David M., Chabon, Jacob J., Scherer, Florian, Stehr, Henning, Liu, Chih Long, Bratman, Scott V., Say, Carmen, Zhou, Li, Carter, Justin N., West, Robert B., Sledge, George W., Shrager, Joseph B., Loo, Billy W., Neal, Joel W., Wakelee, Heather A., Diehn, Maximilian, Alizadeh, Ash A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4907374/
https://ncbi.nlm.nih.gov/pubmed/27018799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt.3520
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