Full length mutant huntingtin is required for altered Ca(2+) signaling and apoptosis of striatal neurons in the YAC mouse model of Huntington’s disease

অনুযায়ী Zhang, Hua, Li, Qin, Graham, Rona K, Slow, Elizabeth, Hayden, Michael R., Bezprozvanny, Ilya
প্রকাশিত 2008

Phosphorylation of Huntingtin at Ser(421) in YAC128 Neurons Is Associated with Protection of YAC128 Neurons from NMDA-Mediated Excitotoxicity and Is Modulated by PP1 and PP2A

অনুযায়ী Metzler, Martina, Gan, Lu, Mazarei, Gelareh, Graham, Rona K., Liu, Lili, Bissada, Nagat, Lu, Ge, Leavitt, Blair R., Hayden, Michael R.
প্রকাশিত J Neurosci (2010)

Polyglutamine-Modulated Striatal Calpain Activity in YAC Transgenic Huntington Disease Mouse Model: Impact on NMDA Receptor Function and Toxicity

অনুযায়ী Cowan, Catherine M., Fan, Mannie M. Y., Fan, Jing, Shehadeh, Jacqueline, Zhang, Lily Y. J., Graham, Rona K., Hayden, Michael R., Raymond, Lynn A.
প্রকাশিত J Neurosci (2008)

Accumulation of N-terminal mutant huntingtin in mouse and monkey models implicated as a pathogenic mechanism in Huntington's disease

অনুযায়ী Wang, Chuan-En, Tydlacka, Suzanne, Orr, Adam L., Yang, Shang-Hsun, Graham, Rona K., Hayden, Michael R., Li, Shihua, Chan, Anthony W.S., Li, Xiao-Jiang
প্রকাশিত 2008

Absence of behavioral abnormalities and neurodegeneration in vivo despite widespread neuronal huntingtin inclusions

অনুযায়ী Slow, Elizabeth J., Graham, Rona K., Osmand, Alexander P., Devon, Rebecca S., Lu, Ge, Deng, Yu, Pearson, Jacqui, Vaid, Kuljeet, Bissada, Nagat, Wetzel, Ronald, Leavitt, Blair R., Hayden, Michael R.
প্রকাশিত 2005

Mice lacking caspase-2 are protected from behavioral changes, but not pathology, in the YAC128 model of Huntington disease

অনুযায়ী Carroll, Jeffrey B, Southwell, Amber L, Graham, Rona K, Lerch, Jason P, Ehrnhoefer, Dagmar E, Cao, Li-Ping, Zhang, Wei-Ning, Deng, Yu, Bissada, Nagat, Henkelman, R Mark, Hayden, Michael R
প্রকাশিত 2011

Full-length huntingtin levels modulate body weight by influencing insulin-like growth factor 1 expression

অনুযায়ী Pouladi, Mahmoud A., Xie, Yuanyun, Skotte, Niels Henning, Ehrnhoefer, Dagmar E., Graham, Rona K., Kim, Jeong Eun, Bissada, Nagat, Yang, X. William, Paganetti, Paolo, Friedlander, Robert M., Leavitt, Blair R., Hayden, Michael R.
প্রকাশিত 2010

The palmitoyl acyltransferase HIP14 shares a high proportion of interactors with huntingtin: implications for a role in the pathogenesis of Huntington's disease

অনুযায়ী Butland, Stefanie L., Sanders, Shaun S., Schmidt, Mandi E., Riechers, Sean-Patrick, Lin, David T.S., Martin, Dale D.O., Vaid, Kuljeet, Graham, Rona K., Singaraja, Roshni R., Wanker, Erich E., Conibear, Elizabeth, Hayden, Michael R.
প্রকাশিত 2014

Cleavage at the 586 Amino Acid Caspase-6 Site in Mutant huntingtin Influences Caspase-6 Activation In Vivo

অনুযায়ী Graham, Rona K., Deng, Yu, Carroll, Jeffery, Vaid, Kuljeet, Cowan, Catherine, Pouladi, Mahmoud A., Metzler, Martina, Bissada, Nagat, Wang, Lili, Faull, Richard L. M., Gray, Michelle, Yang, X. William, Raymond, Lynn A., Hayden, Michael R.
প্রকাশিত 2010

Transgenic Mouse Model Expressing the Caspase 6 Fragment of Mutant Huntingtin

অনুযায়ী Waldron-Roby, Elaine, Ratovitski, Tamara, Wang, XiaoFang, Jiang, Mali, Watkin, Erin, Arbez, Nikolas, Graham, Rona K., Hayden, Michael R., Hou, Zhipeng, Mori, Susumu, Swing, Deborah, Pletnikov, Mikhail, Duan, Wenzhen, Tessarollo, Lino, Ross, Christopher A.
প্রকাশিত 2012

Balance between synaptic versus extrasynaptic NMDA receptor activity influences inclusions and neurotoxicity of mutant huntingtin

অনুযায়ী Okamoto, Shu-ichi, Pouladi, Mahmoud A., Talantova, Maria, Yao, Dongdong, Xia, Peng, Ehrnhoefer, Dagmar E., Zaidi, Rameez, Clemente, Arjay, Kaul, Marcus, Graham, Rona K., Zhang, Dongxian, Chen, H.-S. Vincent, Tong, Gary, Hayden, Michael R., Lipton, Stuart A.
প্রকাশিত 2009

Differential Susceptibility to Excitotoxic Stress in YAC128 Mouse Models of Huntington Disease between Initiation and Progression of Disease

অনুযায়ী Graham, Rona K., Pouladi, Mahmoud A., Joshi, Prasad, Lu, Ge, Deng, Yu, Wu, Nan-Ping, Figueroa, Bryan E., Metzler, Martina, André, Véronique M., Slow, Elizabeth J., Raymond, Lynn, Friedlander, Robert, Levine, Michael S., Leavitt, Blair R., Hayden, Michael R.
প্রকাশিত 2009

Caspase Cleavage of Mutant Huntingtin Precedes Neurodegeneration in Huntington's Disease

অনুযায়ী Wellington, Cheryl L., Ellerby, Lisa M., Gutekunst, Claire-Anne, Rogers, Danny, Warby, Simon, Graham, Rona K., Loubser, Odell, van Raamsdonk, Jeremy, Singaraja, Roshni, Yang, Yu-Zhou, Gafni, Juliette, Bredesen, Dale, Hersch, Steven M., Leavitt, Blair R., Roy, Sophie, Nicholson, Donald W., Hayden, Michael R.
প্রকাশিত J Neurosci (2002)

Suppressing aberrant GluN3A expression rescues NMDA receptor dysfunction, synapse loss and motor and cognitive decline in Huntington's disease models

অনুযায়ী Marco, Sonia, Giralt, Albert, Petrovic, Milos M., Pouladi, Mahmoud A., Martínez-Turrillas, Rebeca, Martínez-Hernández, José, Kaltenbach, Linda S., Torres-Peraza, Jesús, Graham, Rona K., Watanabe, Masahiko, Luján, Rafael, Nakanishi, Nobuki, Lipton, Stuart A., Lo, Donald C., Hayden, Michael R., Alberch, Jordi, Wesseling, John F., Pérez-Otaño, Isabel
প্রকাশিত 2013

Rescue from excitotoxicity and axonal degeneration accompanied by age-dependent behavioral and neuroanatomical alterations in caspase-6-deficient mice

অনুযায়ী Uribe, Valeria, Wong, Bibiana K.Y., Graham, Rona K., Cusack, Corey L., Skotte, Niels H., Pouladi, Mahmoud A., Xie, Yuanyun, Feinberg, Konstantin, Ou, Yimiao, Ouyang, Yingbin, Deng, Yu, Franciosi, Sonia, Bissada, Nagat, Spreeuw, Amanda, Zhang, Weining, Ehrnhoefer, Dagmar E., Vaid, Kuljeet, Miller, Freda D., Deshmukh, Mohanish, Howland, David, Hayden, Michael R.
প্রকাশিত 2012

Systematic interaction network filtering identifies CRMP1 as a novel suppressor of huntingtin misfolding and neurotoxicity

অনুযায়ী Stroedicke, Martin, Bounab, Yacine, Strempel, Nadine, Klockmeier, Konrad, Yigit, Sargon, Friedrich, Ralf P., Chaurasia, Gautam, Li, Shuang, Hesse, Franziska, Riechers, Sean-Patrick, Russ, Jenny, Nicoletti, Cecilia, Boeddrich, Annett, Wiglenda, Thomas, Haenig, Christian, Schnoegl, Sigrid, Fournier, David, Graham, Rona K., Hayden, Michael R., Sigrist, Stephan, Bates, Gillian P., Priller, Josef, Andrade-Navarro, Miguel A., Futschik, Matthias E., Wanker, Erich E.
প্রকাশিত Genome Res (2015)