Full length mutant huntingtin is required for altered Ca(2+) signaling and apoptosis of striatal neurons in the YAC mouse model of Huntington’s disease

Huntington’s disease (HD) is caused by progressive loss of striatal medium spiny neurons (MSN). The molecular trigger of HD is a polyglutamine expansion in the Huntingtin protein (Htt). The mutant Htt protein forms insoluble nuclear aggregates which have been proposed to play a key role in causing n...

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Bibliographische Detailangaben
Hauptverfasser: Zhang, Hua, Li, Qin, Graham, Rona K, Slow, Elizabeth, Hayden, Michael R., Bezprozvanny, Ilya
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2008
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2528878/
https://ncbi.nlm.nih.gov/pubmed/18502655
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2008.03.010
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