Disturbed Ca(2+) signaling and apoptosis of medium spiny neurons in Huntington's disease

Huntington's disease (HD) is caused by polyglutamine expansion (exp) in huntingtin. Here, we used a yeast artificial chromosome (YAC) transgenic mouse model of HD to investigate the connection between disturbed calcium (Ca(2+)) signaling and apoptosis of HD medium spiny neurons (MSN). Repetitiv...

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Detalhes bibliográficos
Main Authors: Tang, Tie-Shan, Slow, Elizabeth, Lupu, Vitalie, Stavrovskaya, Irina G., Sugimori, Mutsuyuki, Llinás, Rodolfo, Kristal, Bruce S., Hayden, Michael R., Bezprozvanny, Ilya
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2005
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC548984/
https://ncbi.nlm.nih.gov/pubmed/15695335
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0409402102
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