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Disturbed Ca(2+) signaling and apoptosis of medium spiny neurons in Huntington's disease
Huntington's disease (HD) is caused by polyglutamine expansion (exp) in huntingtin. Here, we used a yeast artificial chromosome (YAC) transgenic mouse model of HD to investigate the connection between disturbed calcium (Ca(2+)) signaling and apoptosis of HD medium spiny neurons (MSN). Repetitiv...
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| Hauptverfasser: | , , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
National Academy of Sciences
2005
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC548984/ https://ncbi.nlm.nih.gov/pubmed/15695335 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0409402102 |
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