Systematic interaction network filtering identifies CRMP1 as a novel suppressor of huntingtin misfolding and neurotoxicity

Assemblies of huntingtin (HTT) fragments with expanded polyglutamine (polyQ) tracts are a pathological hallmark of Huntington's disease (HD). The molecular mechanisms by which these structures are formed and cause neuronal dysfunction and toxicity are poorly understood. Here, we utilized availa...

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Pubblicato in:Genome Res
Autori principali: Stroedicke, Martin, Bounab, Yacine, Strempel, Nadine, Klockmeier, Konrad, Yigit, Sargon, Friedrich, Ralf P., Chaurasia, Gautam, Li, Shuang, Hesse, Franziska, Riechers, Sean-Patrick, Russ, Jenny, Nicoletti, Cecilia, Boeddrich, Annett, Wiglenda, Thomas, Haenig, Christian, Schnoegl, Sigrid, Fournier, David, Graham, Rona K., Hayden, Michael R., Sigrist, Stephan, Bates, Gillian P., Priller, Josef, Andrade-Navarro, Miguel A., Futschik, Matthias E., Wanker, Erich E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cold Spring Harbor Laboratory Press 2015
Soggetti:
Method
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4417118/
https://ncbi.nlm.nih.gov/pubmed/25908449
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.182444.114
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