Accumulation of Mutant Huntingtin Fragments in Aggresome-like Inclusion Bodies as a Result of Insufficient Protein Degradation

The huntingtin exon 1 proteins with a polyglutamine repeat in the pathological range (51 or 83 glutamines), but not with a polyglutamine tract in the normal range (20 glutamines), form aggresome-like perinuclear inclusions in human 293 Tet-Off cells. These structures contain aggregated, ubiquitinate...

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發表在:	Mol Biol Cell
Principais autores:	Waelter, Stephanie, Boeddrich, Annett, Lurz, Rudi, Scherzinger, Eberhard, Lueder, Gerhild, Lehrach, Hans, Wanker, Erich E.
格式:	Artigo
語言:	Inglês
出版:	American Society for Cell Biology 2001
主題:	Article
在線閱讀:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC34592/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11359930/ https://ncbi.nlm.nih.govhttps://doi.org/10.1091/mbc.12.5.1393
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