Cleavage at the 586 Amino Acid Caspase-6 Site in Mutant huntingtin Influences Caspase-6 Activation In Vivo

Caspase cleavage of huntingtin (htt) and nuclear htt accumulation represent early neuropathological changes in brains of patients with Huntington's disease (HD). However, the relationship between caspase cleavage of htt and caspase activation patterns in the pathogenesis of HD remains poorly un...

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Main Authors: Graham, Rona K., Deng, Yu, Carroll, Jeffery, Vaid, Kuljeet, Cowan, Catherine, Pouladi, Mahmoud A., Metzler, Martina, Bissada, Nagat, Wang, Lili, Faull, Richard L. M., Gray, Michelle, Yang, X. William, Raymond, Lynn A., Hayden, Michael R.
Formato: Artigo
Idioma:Inglês
Publicado: Society for Neuroscience 2010
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3074336/
https://ncbi.nlm.nih.gov/pubmed/21068307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2071-10.2010
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