Small changes, big impact: Posttranslational modifications and function of huntingtin in Huntington disease

Por Ehrnhoefer, Dagmar E., Sutton, Liza, Hayden, Michael R.
Publicado em 2011

Convergent pathogenic pathways in Alzheimer’s and Huntington disease: Shared targets for drug development

Por Ehrnhoefer, Dagmar E., Wong, Bibiana K.Y., Hayden, Michael R.
Publicado em 2011

Mouse models of Huntington disease: variations on a theme

Por Ehrnhoefer, Dagmar E., Butland, Stefanie L., Pouladi, Mahmoud A., Hayden, Michael R.
Publicado em 2009

Constitutive ablation of caspase-6 reduces the inflammatory response and behavioural changes caused by peripheral pro-inflammatory stimuli

Por Ladha, Safia, Qiu, Xiaofan, Casal, Lorenzo, Caron, Nicholas S., Ehrnhoefer, Dagmar E., Hayden, Michael R.
Publicado no Cell Death Discov (2018)

A Huntingtin-based peptide inhibitor of caspase-6 provides protection from mutant Huntingtin-induced motor and behavioral deficits

Por Aharony, Israel, Ehrnhoefer, Dagmar E., Shruster, Adi, Qiu, Xiaofan, Franciosi, Sonia, Hayden, Michael R., Offen, Daniel
Publicado no Hum Mol Genet (2015)

EGCG remodels mature α-synuclein and amyloid-β fibrils and reduces cellular toxicity

Por Bieschke, Jan, Russ, Jenny, Friedrich, Ralf P., Ehrnhoefer, Dagmar E., Wobst, Heike, Neugebauer, Katja, Wanker, Erich E.
Publicado em 2010

A Quantitative Method for the Specific Assessment of Caspase-6 Activity in Cell Culture

Por Ehrnhoefer, Dagmar E., Skotte, Niels H., Savill, Jane, Nguyen, Yen T. N., Ladha, Safia, Cao, Li-Ping, Dullaghan, Edie, Hayden, Michael R.
Publicado em 2011

Palmitoylation of caspase-6 by HIP14 regulates its activation

Por Skotte, Niels H, Sanders, Shaun S, Singaraja, Roshni R, Ehrnhoefer, Dagmar E, Vaid, Kuljeet, Qiu, Xiaofan, Kannan, Srinivasaragavan, Verma, Chandra, Hayden, Michael R
Publicado no Cell Death Differ (2017)

A validated antibody panel for the characterization of tau post-translational modifications

Por Ercan, Ebru, Eid, Sameh, Weber, Christian, Kowalski, Alexandra, Bichmann, Maria, Behrendt, Annika, Matthes, Frank, Krauss, Sybille, Reinhardt, Peter, Fulle, Simone, Ehrnhoefer, Dagmar E.
Publicado no Mol Neurodegener (2017)

HACE1 is essential for astrocyte mitochondrial function and influences Huntington disease phenotypes in vivo

Por Ehrnhoefer, Dagmar E, Southwell, Amber L, Sivasubramanian, Meenalochani, Qiu, Xiaofan, Villanueva, Erika B, Xie, Yuanyun, Waltl, Sabine, Anderson, Lisa, Fazeli, Anita, Casal, Lorenzo, Felczak, Boguslaw, Tsang, Michelle, Hayden, Michael R
Publicado no Hum Mol Genet (2018)

Mice lacking caspase-2 are protected from behavioral changes, but not pathology, in the YAC128 model of Huntington disease

Por Carroll, Jeffrey B, Southwell, Amber L, Graham, Rona K, Lerch, Jason P, Ehrnhoefer, Dagmar E, Cao, Li-Ping, Zhang, Wei-Ning, Deng, Yu, Bissada, Nagat, Henkelman, R Mark, Hayden, Michael R
Publicado em 2011

Full-length huntingtin levels modulate body weight by influencing insulin-like growth factor 1 expression

Por Pouladi, Mahmoud A., Xie, Yuanyun, Skotte, Niels Henning, Ehrnhoefer, Dagmar E., Graham, Rona K., Kim, Jeong Eun, Bissada, Nagat, Yang, X. William, Paganetti, Paolo, Friedlander, Robert M., Leavitt, Blair R., Hayden, Michael R.
Publicado em 2010

Preventing mutant huntingtin proteolysis and intermittent fasting promote autophagy in models of Huntington disease

Por Ehrnhoefer, Dagmar E., Martin, Dale D. O., Schmidt, Mandi E., Qiu, Xiaofan, Ladha, Safia, Caron, Nicholas S., Skotte, Niels H., Nguyen, Yen T. N., Vaid, Kuljeet, Southwell, Amber L., Engemann, Sabine, Franciosi, Sonia, Hayden, Michael R.
Publicado no Acta Neuropathol Commun (2018)

Balance between synaptic versus extrasynaptic NMDA receptor activity influences inclusions and neurotoxicity of mutant huntingtin

Por Okamoto, Shu-ichi, Pouladi, Mahmoud A., Talantova, Maria, Yao, Dongdong, Xia, Peng, Ehrnhoefer, Dagmar E., Zaidi, Rameez, Clemente, Arjay, Kaul, Marcus, Graham, Rona K., Zhang, Dongxian, Chen, H.-S. Vincent, Tong, Gary, Hayden, Michael R., Lipton, Stuart A.
Publicado em 2009

Rescue from excitotoxicity and axonal degeneration accompanied by age-dependent behavioral and neuroanatomical alterations in caspase-6-deficient mice

Por Uribe, Valeria, Wong, Bibiana K.Y., Graham, Rona K., Cusack, Corey L., Skotte, Niels H., Pouladi, Mahmoud A., Xie, Yuanyun, Feinberg, Konstantin, Ou, Yimiao, Ouyang, Yingbin, Deng, Yu, Franciosi, Sonia, Bissada, Nagat, Spreeuw, Amanda, Zhang, Weining, Ehrnhoefer, Dagmar E., Vaid, Kuljeet, Miller, Freda D., Deshmukh, Mohanish, Howland, David, Hayden, Michael R.
Publicado em 2012

HACE1 reduces oxidative stress and mutant Huntingtin toxicity by promoting the NRF2 response

Por Rotblat, Barak, Southwell, Amber L., Ehrnhoefer, Dagmar E., Skotte, Niels H., Metzler, Martina, Franciosi, Sonia, Leprivier, Gabriel, Somasekharan, Syam Prakash, Barokas, Adi, Deng, Yu, Tang, Tiffany, Mathers, Joan, Cetinbas, Naniye, Daugaard, Mads, Kwok, Brian, Li, Liheng, Carnie, Christopher J., Fink, Dieter, Nitsch, Roberto, Galpin, Jason D., Ahern, Christopher A., Melino, Gerry, Penninger, Josef M., Hayden, Michael R., Sorensen, Poul H.
Publicado em 2014