Loading...

Preventing mutant huntingtin proteolysis and intermittent fasting promote autophagy in models of Huntington disease

Huntington disease (HD) is caused by the expression of mutant huntingtin (mHTT) bearing a polyglutamine expansion. In HD, mHTT accumulation is accompanied by a dysfunction in basal autophagy, which manifests as specific defects in cargo loading during selective autophagy. Here we show that the expre...

Full description

Saved in:
Bibliographic Details
Published in:Acta Neuropathol Commun
Main Authors: Ehrnhoefer, Dagmar E., Martin, Dale D. O., Schmidt, Mandi E., Qiu, Xiaofan, Ladha, Safia, Caron, Nicholas S., Skotte, Niels H., Nguyen, Yen T. N., Vaid, Kuljeet, Southwell, Amber L., Engemann, Sabine, Franciosi, Sonia, Hayden, Michael R.
Format: Artigo
Language:Inglês
Published: BioMed Central 2018
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5839066/
https://ncbi.nlm.nih.gov/pubmed/29510748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-018-0518-0
Tags: Add Tag
No Tags, Be the first to tag this record!