Llwytho...
Preventing mutant huntingtin proteolysis and intermittent fasting promote autophagy in models of Huntington disease
Huntington disease (HD) is caused by the expression of mutant huntingtin (mHTT) bearing a polyglutamine expansion. In HD, mHTT accumulation is accompanied by a dysfunction in basal autophagy, which manifests as specific defects in cargo loading during selective autophagy. Here we show that the expre...
Wedi'i Gadw mewn:
| Cyhoeddwyd yn: | Acta Neuropathol Commun |
|---|---|
| Prif Awduron: | , , , , , , , , , , , , |
| Fformat: | Artigo |
| Iaith: | Inglês |
| Cyhoeddwyd: |
BioMed Central
2018
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| Pynciau: | |
| Mynediad Ar-lein: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5839066/ https://ncbi.nlm.nih.gov/pubmed/29510748 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-018-0518-0 |
| Tagiau: |
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