Lung Injury and Cancer: Mechanistic Insights into Ceramide and EGFR Signaling under Cigarette Smoke

por Goldkorn, Tzipora, Filosto, Simone
Publicado 2010

Lung Injury and Lung Cancer Caused by Cigarette Smoke-Induced Oxidative Stress: Molecular Mechanisms and Therapeutic Opportunities Involving the Ceramide-Generating Machinery and E...

por Goldkorn, Tzipora, Filosto, Simone, Chung, Samuel
Publicado 2014

Lung Cancer and Lung Injury: The Dual Role of Ceramide

por Goldkorn, Tzipora, Chung, Samuel, Filosto, Simone
Publicado en Handb Exp Pharmacol (2013)

Cigarette smoke induces aberrant EGF receptor activation which mediates lung cancer development and resistance to tyrosine kinase inhibitors

por Filosto, Simone, Becker, Cathleen R., Goldkorn, Tzipora
Publicado en Mol Cancer Ther (2012)

Src Regulates Cigarette Smoke–Induced Ceramide Generation via Neutral Sphingomyelinase 2 in the Airway Epithelium

por Chung, Samuel, Vu, Simon, Filosto, Simone, Goldkorn, Tzipora
Publicado en Am J Respir Cell Mol Biol (2015)

Neutral Sphingomyelinase 2 (nSMase2) Is a Phosphoprotein Regulated by Calcineurin (PP2B)

por Filosto, Simone, Fry, William, Knowlton, Anne A., Goldkorn, Tzipora
Publicado 2010

Neutral Sphingomyelinase 2 Activity and Protein Stability Are Modulated by Phosphorylation of Five Conserved Serines

por Filosto, Simone, Ashfaq, Majid, Chung, Samuel, Fry, William, Goldkorn, Tzipora
Publicado 2012

Src mediates cigarette smoke-induced resistance to tyrosine kinase inhibitors in NSCLC cells

por Filosto, Simone, Baston, David S., Chung, Samuel, Becker, Cathleen R., Goldkorn, Tzipora
Publicado en Mol Cancer Ther (2013)

Cadmium induces an apoptotic response in sea urchin embryos

por Agnello, Maria, Filosto, Simone, Scudiero, Rosaria, Rinaldi, Anna M., Roccheri, Maria C.
Publicado 2007

EGF Receptor Exposed to Oxidative Stress Acquires Abnormal Phosphorylation and Aberrant Activated Conformation That Impairs Canonical Dimerization

por Filosto, Simone, Khan, Elaine M., Tognon, Emiliana, Becker, Cathleen, Ashfaq, Majid, Ravid, Tommer, Goldkorn, Tzipora
Publicado 2011

Neutral Sphingomyelinase 2: A Novel Target in Cigarette Smoke–Induced Apoptosis and Lung Injury

por Filosto, Simone, Castillo, Sianna, Danielson, Aaron, Franzi, Lisa, Khan, Elaine, Kenyon, Nick, Last, Jerold, Pinkerton, Kent, Tuder, Rubin, Goldkorn, Tzipora
Publicado 2011

Simvastatin inhibits smoke-induced airway epithelial injury: implications for COPD therapy

por Davis, Benjamin B., Zeki, Amir A., Bratt, Jennifer M., Wang, Lei, Filosto, Simone, Walby, William F., Kenyon, Nicholas J., Goldkorn, Tzipora, Schelegle, Edward S., Pinkerton, Kent E.
Publicado en Eur Respir J (2012)

Farnesyltransferase Inhibition Exacerbates Eosinophilic Inflammation and Airway Hyperreactivity in Mice with Experimental Asthma: The Complex Roles of Ras GTPase and Farnesylpyroph...

por Bratt, Jennifer M., Chang, Kevin Y., Rabowsky, Michelle, Franzi, Lisa M., Ott, Sean P., Filosto, Simone, Goldkorn, Tzipora, Arif, Muhammad, Last, Jerold A., Kenyon, Nicholas J., Zeki, Amir A.
Publicado en J Immunol (2018)

PIM1 kinase regulates cell death, tumor growth and chemotherapy response revealing a novel target in triple-negative breast cancer

por Brasó-Maristany, Fara, Filosto, Simone, Catchpole, Steven, Marlow, Rebecca, Quist, Jelmar, Francesch-Domenech, Erika, Plumb, Darren A., Zakka, Leila, Gazinska, Patrycja, Liccardi, Gianmaria, Meier, Pascal, Gris-Oliver, Albert, Cheang, Maggie Chon U, Perdrix-Rosell, Anna, Shafat, Manar, Noël, Elodie, Patel, Nirmesh, McEachern, Kristen, Scaltriti, Maurizio, Castel, Pau, Noor, Farzana, Buus, Richard, Mathew, Sumi, Watkins, Johnathan, Serra, Violeta, Marra, Pierfrancesco, Grigoriadis, Anita, Tutt, Andrew N.
Publicado en Nat Med (2016)