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Src mediates cigarette smoke-induced resistance to tyrosine kinase inhibitors in NSCLC cells

The EGF Receptor (EGFR) is a proto-oncogene commonly dysregulated in several cancers including non-small cell lung cancer (NSCLC) and, thus, is targeted for treatment using tyrosine kinase inhibitors (TKIs) such as Erlotinib. However, despite the efficacy observed in NSCLC patients harboring oncogen...

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Bibliografiske detaljer
Udgivet i:Mol Cancer Ther
Main Authors: Filosto, Simone, Baston, David S., Chung, Samuel, Becker, Cathleen R., Goldkorn, Tzipora
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4370317/
https://ncbi.nlm.nih.gov/pubmed/23686837
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-12-1029
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