PIM1 kinase regulates cell death, tumor growth and chemotherapy response revealing a novel target in triple-negative breast cancer

Triple-negative breast cancers (TNBCs) have poor prognosis and lack targeted therapies. Interrogation of genomic datasets identified increased PIM1 copy number-driven expression in TNBC. RNA interference in breast cancer and non-malignant mammary epithelial cell models revealed a PIM1 dependency in...

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Publicado no:Nat Med
Principais autores: Brasó-Maristany, Fara, Filosto, Simone, Catchpole, Steven, Marlow, Rebecca, Quist, Jelmar, Francesch-Domenech, Erika, Plumb, Darren A., Zakka, Leila, Gazinska, Patrycja, Liccardi, Gianmaria, Meier, Pascal, Gris-Oliver, Albert, Cheang, Maggie Chon U, Perdrix-Rosell, Anna, Shafat, Manar, Noël, Elodie, Patel, Nirmesh, McEachern, Kristen, Scaltriti, Maurizio, Castel, Pau, Noor, Farzana, Buus, Richard, Mathew, Sumi, Watkins, Johnathan, Serra, Violeta, Marra, Pierfrancesco, Grigoriadis, Anita, Tutt, Andrew N.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5552044/
https://ncbi.nlm.nih.gov/pubmed/27775704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.4198
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