Beyond the Aryl Hydrocarbon Receptor: Pathway Interactions in the Hepatotoxicity of 2,3,7,8-Tetrachlorodibenzo-p-dioxin and Related Compounds

od Fader, Kelly A., Zacharewski, Timothy R.
Wydane w Curr Opin Toxicol (2017)

RNA-Seq versus oligonucleotide array assessment of dose-dependent TCDD-elicited hepatic gene expression in mice

od Nault, Rance, Fader, Kelly A, Zacharewski, Tim
Wydane w BMC Genomics (2015)

Loss of liver-specific and sexually dimorphic gene expression by aryl hydrocarbon receptor activation in C57BL/6 mice

od Nault, Rance, Fader, Kelly A., Harkema, Jack R., Zacharewski, Tim
Wydane w PLoS One (2017)

Single-Nuclei RNA Sequencing Assessment of the Hepatic Effects of 2,3,7,8-Tetrachlorodibenzo-p-dioxin

od Nault, Rance, Fader, Kelly A., Bhattacharya, Sudin, Zacharewski, Tim R.
Wydane w Cell Mol Gastroenterol Hepatol (2020)

Lipidomic Evaluation of Aryl Hydrocarbon Receptor-Mediated Hepatic Steatosis in Male and Female Mice Elicited by 2,3,7,8-Tetrachlorodibenzo-p-dioxin

od Nault, Rance, Fader, Kelly A., Lydic, Todd A., Zacharewski, Timothy R.
Wydane w Chem Res Toxicol (2017)

Comparison of Hepatic NRF2 and Aryl Hydrocarbon Receptor Binding in 2,3,7,8-Tetrachlorodibenzo-p-dioxin–Treated Mice Demonstrates NRF2-Independent PKM2 Induction

od Nault, Rance, Doskey, Claire M., Fader, Kelly A., Rockwell, Cheryl E., Zacharewski, Tim
Wydane w Mol Pharmacol (2018)

2,3,7,8-Tetrachlorodibenzo-p-dioxin dose-dependently increases bone mass and decreases marrow adiposity in juvenile mice

od Fader, Kelly A., Nault, Rance, Raehtz, Sandi, McCabe, Laura R., Zacharewski, Timothy R.
Wydane w Toxicol Appl Pharmacol (2018)

2,3,7,8-Tetrachlorodibenzo-p-dioxin abolishes circadian regulation of hepatic metabolic activity in mice

od Fader, Kelly A., Nault, Rance, Doskey, Claire M., Fling, Russell R., Zacharewski, Timothy R.
Wydane w Sci Rep (2019)

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) dysregulates hepatic one carbon metabolism during the progression of steatosis to steatohepatitis with fibrosis in mice

od Fling, Russell R., Doskey, Claire M., Fader, Kelly A., Nault, Rance, Zacharewski, Tim R.
Wydane w Sci Rep (2020)

Convergence of Hepcidin Deficiency, Systemic Iron Overloading, Heme Accumulation, and REV-ERBα/β Activation in Aryl Hydrocarbon Receptor-Elicited Hepatotoxicity

od Fader, Kelly A., Nault, Rance, Kirby, Mathew P., Markous, Gena, Matthews, Jason, Zacharewski, Timothy R.
Wydane w Toxicol Appl Pharmacol (2017)

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD)-elicited effects on bile acid homeostasis: Alterations in biosynthesis, enterohepatic circulation, and microbial metabolism

od Fader, Kelly A., Nault, Rance, Zhang, Chen, Kumagai, Kazuyoshi, Harkema, Jack R., Zacharewski, Timothy R.
Wydane w Sci Rep (2017)

Characterizing the Role of HMG-CoA Reductase in Aryl Hydrocarbon Receptor-Mediated Liver Injury in C57BL/6 Mice

od Dornbos, Peter, Jurgelewicz, Amanda, Fader, Kelly A., Williams, Kurt, Zacharewski, Timothy R., LaPres, John J.
Wydane w Sci Rep (2019)

From the Cover: Coagulation-Driven Hepatic Fibrosis Requires Protease Activated Receptor-1 (PAR-1) in a Mouse Model of TCDD-Elicited Steatohepatitis

od Nault, Rance, Fader, Kelly A., Kopec, Anna K., Harkema, Jack R., Zacharewski, Timothy R., Luyendyk, James P.
Wydane w Toxicol Sci (2016)

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) Alters Hepatic Polyunsaturated Fatty Acid Metabolism and Eicosanoid Biosynthesis in Female Sprague-Dawley Rats

od Doskey, Claire M., Fader, Kelly A., Nault, Rance, Lydic, Todd, Matthews, Jason, Potter, Dave, Sharratt, Bonnie, Williams, Kurt, Zacharewski, Tim
Wydane w Toxicol Appl Pharmacol (2020)

Pyruvate Kinase Isoform Switching and Hepatic Metabolic Reprogramming by the Environmental Contaminant 2,3,7,8-Tetrachlorodibenzo-p-Dioxin

od Nault, Rance, Fader, Kelly A., Kirby, Mathew P., Ahmed, Shaimaa, Matthews, Jason, Jones, A. Daniel, Lunt, Sophia Y., Zacharewski, Timothy R.
Wydane w Toxicol Sci (2016)

TCDD influences reservoir of antibiotic resistance genes in murine gut microbiome

od Stedtfeld, Robert D., Stedtfeld, Tiffany M., Fader, Kelly A., Williams, Maggie R., Bhaduri, Prianca, Quensen, John, Zacharewski, Timothy R., Tiedje, James M., Hashsham, Syed A.
Wydane w FEMS Microbiol Ecol (2017)

Dose-Dependent Metabolic Reprogramming and Differential Gene Expression in TCDD-Elicited Hepatic Fibrosis

od Nault, Rance, Fader, Kelly A., Ammendolia, Dustin A., Dornbos, Peter, Potter, Dave, Sharratt, Bonnie, Kumagai, Kazuyoshi, Harkema, Jack R., Lunt, Sophia Y., Matthews, Jason, Zacharewski, Tim
Wydane w Toxicol Sci (2016)

Liver-specific loss of Perilipin 2 alleviates diet-induced hepatic steatosis, inflammation, and fibrosis

od Najt, Charles P., Senthivinayagam, Subramanian, Aljazi, Mohammad B., Fader, Kelly A., Olenic, Sandra D., Brock, Julienne R. L., Lydic, Todd A., Jones, A. Daniel, Atshaves, Barbara P.
Wydane w Am J Physiol Gastrointest Liver Physiol (2016)

2,3,7,8-Tetrachlorodibenzo-p-Dioxin Alters Lipid Metabolism and Depletes Immune Cell Populations in the Jejunum of C57BL/6 Mice

od Fader, Kelly A., Nault, Rance, Ammendolia, Dustin A., Harkema, Jack R., Williams, Kurt J., Crawford, Robert B., Kaminski, Norbert E., Potter, Dave, Sharratt, Bonnie, Zacharewski, Timothy R.
Wydane w Toxicol Sci (2015)