Comparison of Hepatic NRF2 and Aryl Hydrocarbon Receptor Binding in 2,3,7,8-Tetrachlorodibenzo-p-dioxin–Treated Mice Demonstrates NRF2-Independent PKM2 Induction

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) induces hepatic oxidative stress following activation of the aryl hydrocarbon receptor (AhR). Our recent studies showed TCDD induced pyruvate kinase muscle isoform 2 (Pkm2) as a novel antioxidant response in normal differentiated hepatocytes. To investigate...

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Argitaratua izan da:Mol Pharmacol
Egile Nagusiak: Nault, Rance, Doskey, Claire M., Fader, Kelly A., Rockwell, Cheryl E., Zacharewski, Tim
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: The American Society for Pharmacology and Experimental Therapeutics 2018
Gaiak:
Articles
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6022803/
https://ncbi.nlm.nih.gov/pubmed/29752288
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.118.112144
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