Dose-Dependent Metabolic Reprogramming and Differential Gene Expression in TCDD-Elicited Hepatic Fibrosis

We have previously shown that in response to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-elicited NAFLD progression, central carbon, glutaminolysis, and serine/folate metabolism are reprogrammed to support NADPH production and ROS defenses. To further investigate underlying dose-dependent responses a...

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Pubblicato in:Toxicol Sci
Autori principali: Nault, Rance, Fader, Kelly A., Ammendolia, Dustin A., Dornbos, Peter, Potter, Dave, Sharratt, Bonnie, Kumagai, Kazuyoshi, Harkema, Jack R., Lunt, Sophia Y., Matthews, Jason, Zacharewski, Tim
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2016
Soggetti:
Metabolic Reprogramming in TCDD Hepatic Fibrosis
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5139066/
https://ncbi.nlm.nih.gov/pubmed/27562557
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfw163
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