Liver-specific loss of Perilipin 2 alleviates diet-induced hepatic steatosis, inflammation, and fibrosis

Hepatic inflammation and fibrosis are key elements in the pathogenesis of nonalcoholic steatohepatitis (NASH), a progressive liver disease initiated by excess hepatic lipid accumulation. Lipid droplet protein Perilipin 2 (Plin2) alleviates dietary-induced hepatic steatosis when globally ablated; how...

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Udgivet i:Am J Physiol Gastrointest Liver Physiol
Main Authors: Najt, Charles P., Senthivinayagam, Subramanian, Aljazi, Mohammad B., Fader, Kelly A., Olenic, Sandra D., Brock, Julienne R. L., Lydic, Todd A., Jones, A. Daniel, Atshaves, Barbara P.
Format: Artigo
Sprog:Inglês
Udgivet: American Physiological Society 2016
Fag:
Liver and Biliary Tract Physiology/Pathophysiology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4867327/
https://ncbi.nlm.nih.gov/pubmed/26968211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00436.2015
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