2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) Alters Hepatic Polyunsaturated Fatty Acid Metabolism and Eicosanoid Biosynthesis in Female Sprague-Dawley Rats

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a potent aryl hydrocarbon receptor (AhR) agonist that elicits a broad spectrum of dose-dependent hepatic effects including lipid accumulation, inflammation, and fibrosis. To determine the role of inflammatory lipid mediators in TCDD-mediated hepatotoxici...

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Publicado en:Toxicol Appl Pharmacol
Autores principales: Doskey, Claire M., Fader, Kelly A., Nault, Rance, Lydic, Todd, Matthews, Jason, Potter, Dave, Sharratt, Bonnie, Williams, Kurt, Zacharewski, Tim
Formato: Artigo
Lenguaje:Inglês
Publicado: 2020
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7294678/
https://ncbi.nlm.nih.gov/pubmed/32387183
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.taap.2020.115034
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