2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) dysregulates hepatic one carbon metabolism during the progression of steatosis to steatohepatitis with fibrosis in mice

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD), a persistent environmental contaminant, induces steatosis that can progress to steatohepatitis with fibrosis, pathologies that parallel stages in the development of non-alcoholic fatty liver disease (NAFLD). Coincidently, one carbon metabolism (OCM) gene e...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Fling, Russell R., Doskey, Claire M., Fader, Kelly A., Nault, Rance, Zacharewski, Tim R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7481292/
https://ncbi.nlm.nih.gov/pubmed/32908189
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-71795-0
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