Central administration of angiotensin IV rapidly enhances novel object recognition among mice

le Paris, Jason J., Eans, Shainnel O., Mizrachi, Elisa, Reilley, Kate J., Ganno, Michelle L., McLaughlin, Jay P.
Foilsithe 2013

The Macrocyclic Peptide Natural Product CJ-15,208 is Orally Active and Prevents Reinstatement of Extinguished Cocaine Seeking Behavior()

le Aldrich, Jane V., Senadheera, Sanjeewa N., Ross, Nicolette C., Ganno, Michelle L., Eans, Shainnel O., McLaughlin, Jay P.
Foilsithe 2013

Selective κ receptor partial agonist HS666 produces potent antinociception without inducing aversion after i.c.v. administration in mice

le Spetea, Mariana, Eans, Shainnel O, Ganno, Michelle L, Lantero, Aquilino, Mairegger, Michael, Toll, Lawrence, Schmidhammer, Helmut, McLaughlin, Jay P
Foilsithe in Br J Pharmacol (2017)

Antinociceptive Activity of Thiazole-containing Cyclized DAMGO and Leu-(Met) Enkephalin Analogs

le Harris, Hannah M., Eans, Shainnel O., Ganno, Michelle L., Davis, Jennifer C., Dooley, Colette T., McLaughlin, Jay P., Nefzi, Adel
Foilsithe in Org Biomol Chem (2019)

The macrocyclic tetrapeptide [D-Trp]CJ-15,208 produces short-acting κ opioid receptor antagonism in the CNS after oral administration

le Eans, Shainnel O, Ganno, Michelle L, Reilley, Kate J, Patkar, Kshitij A, Senadheera, Sanjeewa N, Aldrich, Jane V, McLaughlin, Jay P
Foilsithe 2013

Nonpeptide Small Molecule Agonist and Antagonist Original Leads for Neuropeptide FF1 and FF2 Receptors

le Journigan, V. Blair, Mésangeau, Christophe, Vyas, Neha, Eans, Shainnel O., Cutler, Stephen J., McLaughlin, Jay P., Mollereau, Catherine, McCurdy, Christopher R.
Foilsithe in J Med Chem (2014)

Peptides derived from the prohormone proNPQ/spexin are potent central modulators of cardiovascular and renal function and nociception

le Toll, Lawrence, Khroyan, Taline V., Sonmez, Kemal, Ozawa, Akihiko, Lindberg, Iris, McLaughlin, Jay P., Eans, Shainnel O., Shahien, Amir A., Kapusta, Daniel R.
Foilsithe 2012

Characterization of Sigma 1 Receptor Antagonist CM-304 and Its Analog, AZ-66: Novel Therapeutics Against Allodynia and Induced Pain

le Cirino, Thomas J., Eans, Shainnel O., Medina, Jessica M., Wilson, Lisa L., Mottinelli, Marco, Intagliata, Sebastiano, McCurdy, Christopher R., McLaughlin, Jay P.
Foilsithe in Front Pharmacol (2019)

A stable isotope dilution tandem mass spectrometry method of major kavalactones and its applications

le Wang, Yi, Eans, Shainnel O., Stacy, Heather M., Narayanapillai, Sreekanth C., Sharma, Abhisheak, Fujioka, Naomi, Haddad, Linda, McLaughlin, Jay, Avery, Bonnie A., Xing, Chengguo
Foilsithe in PLoS One (2018)

Phenylalanine Stereoisomers of CJ-15,208 and [d-Trp]CJ-15,208 Exhibit Distinctly Different Opioid Activity Profiles

le Brice-Tutt, Ariana C., Senadheera, Sanjeewa N., Ganno, Michelle L., Eans, Shainnel O., Khaliq, Tanvir, Murray, Thomas F., McLaughlin, Jay P., Aldrich, Jane V.
Foilsithe in Molecules (2020)

Kratom alkaloids, natural and semi-synthetic, show less physical dependence and ameliorate opioid withdrawal

le Wilson, Lisa L., Chakraborty, Soumen, Eans, Shainnel O., Cirino, Thomas J., Stacy, Heather M., Simons, Chloe A., Uprety, Rajendra, Majumdar, Susruta, McLaughlin, Jay P.
Foilsithe in Cell Mol Neurobiol (2021)

Unexpected Opioid Activity Profiles of Analogs of the Novel Peptide Kappa Opioid Receptor Ligand CJ-15,208

le Aldrich, Jane V., Kulkarni, Santosh S., Senadheera, Sanjeewa N., Ross, Nicolette C., Reilley, Kate J., Eans, Shainnel O., Ganno, Michelle L., Murray, Thomas F., McLaughlin, Jay P.
Foilsithe 2011

Synthesis and Characterization of a Dual Kappa-Delta Opioid Receptor Agonist Analgesic Blocking Cocaine Reward Behavior

le Váradi, András, Marrone, Gina F., Eans, Shainnel O., Ganno, Michelle L., Subrath, Joan J., Rouzic, Valerie Le, Hunkele, Amanda, Pasternak, Gavril W., McLaughlin, Jay P., Majumdar, Susruta
Foilsithe in ACS Chem Neurosci (2015)

Direct Phenotypic Screening in Mice: Identification of Individual, Novel Antinociceptive Compounds from a Library of 734 821 Pyrrolidine Bis-piperazines

le Houghten, Richard A., Ganno, Michelle L., McLaughlin, Jay P., Dooley, Colette T., Eans, Shainnel O., Santos, Radleigh G., LaVoi, Travis, Nefzi, Adel, Welmaker, Greg, Giulianotti, Marc A., Toll, Lawrence
Foilsithe in ACS Comb Sci (2015)

Multifunctional opioid receptor agonism and antagonism by a novel macrocyclic tetrapeptide prevents reinstatement of morphine‐seeking behaviour

le Brice‐Tutt, Ariana C., Wilson, Lisa L., Eans, Shainnel O., Stacy, Heather M., Simons, Chloe A., Simpson, Grant G., Coleman, Jeremy S., Ferracane, Michael J., Aldrich, Jane V., McLaughlin, Jay P.
Foilsithe in Br J Pharmacol (2020)

Preventing Morphine-Seeking Behavior through the Re-Engineering of Vincamine’s Biological Activity

le Norwood, Verrill M., Brice-Tutt, Ariana C., Eans, Shainnel O., Stacy, Heather M., Shi, Guqin, Ratnayake, Ranjala, Rocca, James R., Abboud, Khalil A., Li, Chenglong, Luesch, Hendrik, McLaughlin, Jay P., Huigens, Robert W.
Foilsithe in J Med Chem (2020)

Kratom Alkaloids as Probes for Opioid Receptor Function: Pharmacological Characterization of Minor Indole and Oxindole Alkaloids from Kratom

le Chakraborty, Soumen, Uprety, Rajendra, Daibani, Amal E., Rouzic, Valerie L., Hunkele, Amanda, Appourchaux, Kevin, Eans, Shainnel O., Nuthikattu, Nitin, Jilakara, Rahul, Thammavong, Lisa, Pasternak, Gavril W., Pan, Ying-Xian, McLaughlin, Jay P., Che, Tao, Majumdar, Susruta
Foilsithe in ACS Chem Neurosci (2021)

Conditional Human Immunodeficiency Virus Transactivator of Transcription Protein Expression Induces Depression-like Effects and Oxidative Stress

le McLaughlin, Jay P., Paris, Jason J., Mintzopoulos, Dionyssios, Hymel, Kristen A., Kim, Jae K., Cirino, Thomas J., Gillis, Timothy E., Eans, Shainnel O., Vitaliano, Gordana D., Medina, Jessica M., Krapf, Richard C., Stacy, Heather M., Kaufman, Marc J.
Foilsithe in Biol Psychiatry Cogn Neurosci Neuroimaging (2017)

Positive allosteric modulation of the mu-opioid receptor produces analgesia with reduced side effects

le Kandasamy, Ram, Hillhouse, Todd M., Livingston, Kathryn E., Kochan, Kelsey E., Meurice, Claire, Eans, Shainnel O., Li, Ming-Hua, White, Andrew D., Roques, Bernard P., McLaughlin, Jay P., Ingram, Susan L., Burford, Neil T., Alt, Andrew, Traynor, John R.
Foilsithe in Proc Natl Acad Sci U S A (2021)

Mitragynine/Corynantheidine Pseudoindoxyls As Opioid Analgesics with Mu Agonism and Delta Antagonism, Which Do Not Recruit β-Arrestin-2

le Váradi, András, Marrone, Gina F., Palmer, Travis C., Narayan, Ankita, Szabó, Márton R., Le Rouzic, Valerie, Grinnell, Steven G., Subrath, Joan J., Warner, Evelyn, Kalra, Sanjay, Hunkele, Amanda, Pagirsky, Jeremy, Eans, Shainnel O., Medina, Jessica M., Xu, Jin, Pan, Ying-Xian, Borics, Attila, Pasternak, Gavril W., McLaughlin, Jay P., Majumdar, Susruta
Foilsithe in J Med Chem (2016)